MCC as Directly Compressible Filler: MCC is the most compressible of all the direct compression fillers and has the highest dilution potential and capacity, which is defined as the amount of active ingredient that a diluent can successfully carry in the direct compression technique. This can be explained on the basis of the nature of MCC particles themselves, which are held together by hydrogen bonds in the same way that a paper sheet or an ice cube is bonded. Hydrogen bonds on adjacent cellulose molecules account solely for strength and cohesiveness. MCC particles are deformed plastically under compaction forces to yield an extremely large number of clean surfaces brought in contact during this deformation forming a strong compact even under low compression forces.
Another factor of MCC being the most favorite diluent is its low bulk density. An excipient with low bulk density and large particle size distribution will exhibit a high dilution potential on a weight basis, optimum packing density, and coverage of drug and other excipient materials.
Which MCC grades suit direct compression
| Grade | Average particle size | Why it helps in direct compression |
|---|---|---|
| PH102 | 100 μm | Larger particles flow better than PH101 |
| PH112 | 100 μm | As PH102 with much reduced moisture, for moisture-sensitive actives |
| PH200 | 250 μm | Highest flow; improves content uniformity |
| PH301 | 50 μm | Denser than PH101; better flow and tablet weight uniformity |
PH101 (50 μm) also works in direct compression but is the standard choice for wet granulation. Specifications and documents for every grade are on the microcrystalline cellulose product page.
FAQ
Why is MCC good for direct compression?
MCC particles deform plastically under pressure and bond through hydrogen bonds, so they form strong tablets even at low compression force, and MCC can carry a high proportion of active ingredient.
Which MCC grade is best for direct compression?
PH102 or PH200 when flow matters; PH112 when the active is moisture-sensitive; PH301 for denser blends and better weight uniformity.
