Microcrystalline cellulose (MCC) is sold in grades that differ in particle size, moisture and bulk density. Choosing the right grade matters more than choosing the supplier name on the bag. This guide explains the common PH grades and how to pick one. Full specifications are on the microcrystalline cellulose product page.
The PH grades at a glance
| Grade | Average particle size | What sets it apart | Typical use |
|---|---|---|---|
| PH101 | 50 µm | Fine standard grade | Wet granulation and direct compression |
| PH102 | 100 µm | Coarser, flows better | Direct compression |
| PH103 | 50 µm | As PH101 with lower moisture | Moisture-sensitive actives |
| PH105 | 50 µm | Most compressible | Direct compression of coarse materials |
| PH112 | 100 µm | As PH102 with much lower moisture | Moisture-sensitive actives, direct compression |
| PH113 | 50 µm | As PH101 with much lower moisture | Moisture-sensitive actives |
| PH200 | 250 µm | Large particles | Flow and weight uniformity on fast presses |
| PH301 | 50 µm | Denser PH101 | Better flow, smaller tablets |
| PH302 | 100 µm | Denser PH102 | Better flow, smaller tablets |
How to choose
- Wet granulation: start with PH101.
- Direct compression: start with PH102; move to PH200 if flow or weight variation is a problem.
- Moisture-sensitive actives: use a low-moisture grade (PH103, PH112 or PH113).
- Small or high-dose tablets: a high-density grade (PH301 or PH302) fits more material into the die.
- Food: see microcrystalline cellulose in food.
Related guides
- MCC as a directly compressible filler
- MCC as a wet granulation filler
- How microcrystalline cellulose is made
FAQ
What is the difference between PH101 and PH102?
PH101 has an average particle size of about 50 µm and suits wet granulation; PH102 is about 100 µm, flows better and is preferred for direct compression.
Which MCC grade is best for direct compression?
PH102 is the usual starting point. PH200 helps when flow is poor, and PH105 when maximum compressibility is needed.
What are low-moisture MCC grades for?
PH103, PH112 and PH113 are used with actives that degrade in the presence of moisture.
