Sodium Carboxymethyl Cellulose Function and Application
What is Sodium Carboxymethyl Cellulose (also known as: sodium carboxymethyl cellulose, carboxymethyl cellulose, cmc, Carboxymethyl, Cellulose Sodium, Sodium salt of Caboxy Methyl Cellulose) is the most widely used in the world today, the amount of The largest cellulose varieties.
What is carboxymethylcellulose, which was first produced by Germany in 1918 and was granted patents in 1921. And then in Europe to complete the commercial production. At that time only for rough goods, used as colloids and adhesives. 1936 ~ 1941, the practical use of sodium carboxymethyl cellulose research seminar was lively, invented a number of appropriate and enlightening patents. During the Second World War, Germany used sodium carboxymethyl cellulose for synthetic detergents. Hercules company in 1943 for the United States for the initial production of sodium carboxymethyl cellulose, and in 1946 produced refined sodium carboxymethyl cellulose products, the goods are recognized as safe food additives. The seventies of last century, China began to use, the beginning of the nineties widespread use. Is the world’s most widely used, the largest amount of cellulose varieties.
What is carboxymethyl cellulose, this product is the sodium salt of cellulose carboxymethyl ether, is anionic cellulose ether, white or milky white fibrous powder or particles, the density of 0.5-0.7 g / cubic centimeter, almost odorless , Tasteless, hygroscopic. Easy to lax in the water into a clear gelatinous solution, insoluble in organic solvents such as ethanol. 1% aqueous solution pH 6.5 ~ 8.5, when the pH> 10 or <5, the viscosity of the mortar decreased significantly at pH = 7 when the best function. The heat stability at 20 ℃ below the rapid increase in viscosity, 45 ℃ change slowly, more than 80 ℃ long-term heating can make its colloid degeneration and viscosity significantly decreased. Soluble in water, the solution is clear; in alkaline solution is very stable, case of acid is easy to hydrolysis, pH value of 2-3 will appear when the accumulation of polyvalent metal salt will appear to reflect the accumulation.
What is carboxymethyl cellulose, what is used as a thickening agent in the food industry, as a drug carrier in the pharmaceutical industry, as a binder in the daily chemical industry, and as an anti-coagulant. Printing and dyeing industry used as sizing agent and printing paste protection colloid and so on. In the petrochemical industry can be used as oil fracturing fluid composition.
What is carboxymethyl cellulose, sodium carboxymethyl cellulose is compatible with strong acid solutions, soluble iron salts, and some other metals such as aluminum, mercury and zinc, when mixed with PH & lt; 2, and with 95% ethanol , Will be piled up.
Sodium carboxymethyl cellulose and gelatin and pectin can form co-coagulants, but also can form a complex with collagen, can accumulate some positively charged protein.
Carboxymethyl cellulose is what is usually made of natural cellulose and caustic soda and a chloroacetic acid after the reaction of an anionic polymer compounds, molecular weight 6400 (± 1 000). The primary by-products are sodium chloride and sodium glycolate. CMC is a natural cellulose modification. The Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) have officially called it “modified cellulose”.
The primary objective of measuring CMC quality is the degree of substitution (DS) and purity. General DS is not the same as the nature of the CMC is not the same; substitution increased, increased solubility, solution transparency and stability of the better. It is reported that CMC replacement degree of 0.7 to 1.2 when the transparency is better, the viscosity of the aqueous solution in the pH value of 6 to 9 when the largest. In order to ensure its quality, in addition to the choice of etherification agent, but also must consider the impact of substitution and purity of some factors, such as alkali and etherification agent between the amount of contact, etherification time, system water content, temperature, pH, Concentration and salts.
This product has a bonding, thickening, enhanced, emulsified, water, suspension and so on.
High viscosity aqueous solution of sodium carboxymethyl cellulose (CMC)
High viscosity aqueous solution of sodium carboxymethyl cellulose (CMC)
The use of CMC in food
FAO and WHO have agreed to use pure CMC for food, which is approved by highly stringent biology, toxicology, and trials. The international standard safe intake (ADI) is 25 mg / (kg · d) , That is about 1.5 g / d per person. It has been reported that some people test the intake reached 10 kg also no toxic response. CMC is not only an excellent emulsifying stabilizer, thickener, but also has excellent freeze, melting stability, and can improve the flavor of the product and extend the storage time. In soy milk, ice cream, ice cream, jelly, beverages, cans in the amount of about 1% to 1.5%. CMC can also be vinegar, soy sauce, vegetable oil, fruit juice, gravy, vegetable juice and other components constitute a stable emulsion of lax, the amount of 0.2% to 0.5%. Especially the dynamic, vegetable oil, protein and aqueous emulsion function is extremely good, can make it constitute a stable homogeneous emulsion. Because of its safe and reliable, therefore, its use from the national food hygiene standards ADI restrictions. CMC has been continuously developed in the food sector, and the use of sodium carboxymethyl cellulose in wine production has also been initiated.
CMC in the use of medicine
What is carboxymethylcellulose, emulsifying stabilizers for pharmaceuticals, binders for tablets and film formers in the pharmaceutical industry. Some people through the root and animal experiments confirmed that CMC is safe and reliable anti-cancer drug carrier. With the CMC as membrane data, research and development of Chinese medicine Yang Yin Sheng muscle powder modified dosage form – – Yin Yin sarcoma, can be used for skin grinding surgical wound and traumatic wound. Animal model studies have shown that the film to avoid wound infection, and gauze dressings no significant difference in the control of wound tissue fluid exudation and wound healing, the film was significantly better than gauze dressings, and reduce postoperative edema and wound stimulation effect. The use of polyvinyl alcohol: sodium carboxymethyl cellulose: polycarboxylate 3: 6: 1 ratio of the film made of the best prescription, adhesion and release rate are added in the addition of mucosal adhesive sustained-release film The adhesion of the extension agent in the oral cavity of the time of stay and the efficacy of drugs in the preparation have made significant progress. Bupivacaine is a potent part of the anesthetic, but it is sometimes poisoned when the more severe cardiovascular side effects, so the clinical use of bupivacaine in a wide range of its response to the prevention and treatment of toxicity has been more focused. Pharmacy studies have shown that CIVIC as a sustained-release substance with a picocaine solution can significantly reduce the side effects of the drug. In the PRK operation, the use of low concentrations of ground and non-steroidal anti-inflammatory drugs combined with CMC can significantly relieve postoperative pain. Prevention of abdominal surgery after peritoneal adhesions, reduce the incidence of intestinal obstruction is one of the most concerned about clinical surgery. Studies have shown that, CMC to reduce the degree of postoperative peritoneal adhesions significantly better than sodium hyaluronate, can be used as a useful method to avoid the onset of peritoneal adhesions. CMC for the treatment of liver cancer ductal hepatic artery infusion of anti-cancer drugs, can significantly extend the anticancer drug in the tumor stay time, enhance the anti-tumor force, progressive healing effect. In animal medicine, CMC is also widely used. It has been reported  that the infants with intraperitoneal instillation of 1% CMC solution to prevent livestock dystocia, genital tract surgery after abdominal adhesions have a significant role.
Carboxymethylcellulose is what is used in other industries
In the detergent, CMC can be used as anti-dust re-accumulation agent, especially for hydrophobic synthetic fiber fabric of dust and then re-accumulation effect, significantly better than carboxymethyl fiber.
What is carboxymethyl cellulose in oil drilling can be used to protect the wells as a mud stabilizer, water retaining agent, the amount of each well is shallow wells 2.3t, deep wells 5.6t;
In the textile industry as a sizing agent, printing paste thickener, textile printing and hard to clean up. For the sizing agent can improve the solubility and viscosity, and simple desizing; as a stiff picking agent, the amount of more than 95%; for sizing agent, serous membrane strength, can be significantly improved twist function; Protein and carboxymethyl cellulose as a fixed glucose oxidase matrix, fixed glucose oxidase and carboxylic acid ferrocene, made of glucose biosensor has a high sensitivity and stability. It was noted that the chromatographic function of the resulting thin layer was best when the silica gel homogenate was prepared with CMC solution at a concentration of 1% (w / v), and the thin plate coated with the optimized conditions Appropriate layer strength, suitable for a variety of loading skills, easy to operate. CMC is adhered to most fibers, can improve the connection between the fibers, the viscosity of the stable function to ensure uniformity of the sizing, and then improve the efficiency of weaving. Can also be used for textile cleaning agents, especially the permanent anti-wrinkle clean up, to bring durability to the fabric changes.
Carboxymethyl cellulose is what can be used as paint anti-settling agent, emulsifier, slag agent, leveling agent, adhesive, can make the coating of solid parts evenly dispersed in the solvent, the paint long-term non-stratification, Also a lot used in paint.
Carboxymethyl cellulose is used as a flocculant in the removal of calcium ions than sodium gluconate more useful for cationic exchange, the exchange capacity of up to 1.6 ml / g.
Carboxymethylcellulose What is used in the paper industry as a paper sizing agent can significantly improve the paper’s dry strength and wet strength and oil resistance, ink absorption and water resistance.
What is carboxymethylcellulose in cosmetics as a hydrosol, used as a thickener in toothpaste, at a rate of about 5%.
Carboxymethyl cellulose is what can be used as flocculant, chelating agent, emulsifier, thickener, water retaining agent, sizing agent, film forming materials, etc. Also widely used in electronics, pesticide, leather, plastic, printing, ceramics, toothpaste , Daily chemical and other areas, and because of its excellent features and wide range of usefulness, but also continue to open up new areas of use, the market prospect is very broad.
(1) This product is a strong acid, alkali, heavy metal ions (such as aluminum, zinc, mercury, silver, iron, etc.) compatibility are taboo.
(2) This product is allowed to intake of 0 ~ 25mg / kg · d.
Shandong Dongda Cellulose Co., Ltd. (http://www.sdcmcchina.com/), is a professional manufacturer of sodium carboxymethyl cellulose, sodium carboxymethyl starch, xanthan gum production enterprises, specializing in the production of carboxyl Methyl cellulose sodium, sodium carboxymethyl starch, xanthan gum. Have a strong technical force, advanced production technology and equipment. Dongda Cellulose Co., Ltd. for all employees at home and abroad to provide high-tech, high-performance, high-quality products. We warmly welcome customers at home and abroad cooperation and win-win situation.