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Tag Archive : Microcrystalline cellulose

Hydroxyethy Cellulose

Microcrystalline cellulose as Directly Compressible Filler

MCC as Directly Compressible Filler: MCC is the most compressible of all the direct compression fillers and has the highest dilution potential and capacity, which is defined as the amount of active ingredient that a diluent can successfully carry in the direct compression technique. [4] This can be explained on the basis of the nature of MCC particles themselves, which are held together by hydrogen bonds in the same way that a paper sheet or an ice cube is bonded. Hydrogen bonds on adjacent cellulose molecules account solely for strength and cohesiveness. MCC particles are deformed plastically under compaction forces to yield an extremely large number of clean surfaces brought in contact during this deformation forming a strong compact even under low compression forces. [5]

Another factor of MCC being the most favorite diluent is its low bulk density. An excipient with low bulk density and large particle size distribution will exhibit a high dilution potential on a weight basis, optimum packing density, and coverage of drug and other excipient materials. [4]Avicel grades (Avicel PH-102 SCG, Avicel HFE-102, Avicel PH-200, Avicel PH-302) provide excipient solutions to many challenges of direct compression formulations including improved flow, better compressibility, and accommodation of moisture-sensitive actives. [6]Overall, as direct compression filler, Avicel promotes efficient dry blending of ingredients and produces tablets with high hardness levels and low friability levels with excellent compression. It produces tablets of superior whiteness and color stability.

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Microcrystalline cellulose function used in food and others

FUNCTION

Microcrystalline cellulose, like cellulose, is a dream product for food manufacturers. Its addition to processed foods ensures uniform texture, and consistency of the product’s qualities, at many different temperatures and pH levels. It will even ensure that frozen products are delivered from freezing unaltered when thawed. Microcrystalline cellulose is also capable of emulsifying, that is, preventing the separation of oils and other ingredients that would not normally mix. Microcrystalline cellulose prevents powders from caking, stabilizes foam consistency, and makes frostings and toppings opaque for visual appeal.

Another area where cellulose is useful to food manufacturers is in adding bulk. Microcrystalline cellulose is used as a filler to increase the volume and mass of a product while reducing the use of more expensive items like flour, sugar or fat. As an added advantage, cellulose is not digested, so it does not add any calories to food. In fact, cellulose also has the ability to hold moisture, so it is used as a fat replacement; for example, it is added to prepared, diet meat products to make them juicy without fat content.

Cellulose is a natural polysaccharide (complex carbohydrate) found in all plant material. Microcrystalline cellulose consists of a specific segment of the cellulose molecule, which is chemically “snipped off” and isolated into a powder. There are several forms of microcrystalline cellulose, each performing different functions. One form is used in nutritional supplements as dietary fiber. Microcrystalline cellulose is used as an alternative to a modified cellulose, such as carboxymethyl, or hydroxypropyl cellulose.

OTHER USE AND INDUSTRIES

Microcrystalline cellulose is widely used in the pharmaceutical industry as an excipient, that is, an inert substance which binds with the active ingredient for safe delivery into the bloodstream. It prevents the medicine from being destroyed in the stomach. It may also be a filler to fill out tablets or capsules when the volume of medicine is small.

HEALTH EFFECTS

Microcrystalline cellulose is an extremely inert, natural substance, which is not digested. It passes right through our system. There are claims that taking cellulose can cleanse the colon, but the actual effects of taking it are unverified. Some claim that consuming microcrystalline cellulose can aid in weight loss, because it absorbs moisture and expands, giving a feeling of being “full”. This claim is also unproven.

ORIGINS

Microcrystalline cellulose is derived from cellulose, the indigestible part of plant material. Cellulose is a carbohydrate, which in industry is derived most commonly from wood or cotton, but may come from bamboo, or any other plant matter. To produce microcrystalline cellulose, wood pulp is treated with an acid to break up the cellulose molecules, and the desired section, the microcrystal, is isolated. It appears as a white powder.

Hydroxyethy Cellulose

Microcrystalline cellulose introduce

Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production.[1] The most common form is used in vitamin supplements or tablets. It is also used in plaque assays for counting viruses, as an alternative to carboxymethylcellulose.[2]

In many ways, cellulose makes the ideal excipient. A naturally occurring polymer, it is composed of glucose units connected by a 1-4 beta glycosidic bond. These linear cellulose chains are bundled together as microfibril spiralled together in the walls of plant cell. Each microfibril exhibits a high degree of three-dimensional internal bonding resulting in a crystalline structure that is insoluble in water and resistant to reagents. There are, however, relatively weak segments of the microfibril with weaker internal bonding. These are called amorphous regions; some argue that they are more accurately called dislocations, because of the single-phase structure of microfibrils. The crystalline region is isolated to produce microcrystalline cellulose.

Microcrystalline cellulose

Microcrystalline cellulose, like cellulose, is a dream product for food manufacturers. Its addition to processed foods ensures uniform texture, and consistency of the product’s qualities, at many different temperatures and pH levels. It will even ensure that frozen products are delivered from freezing unaltered when thawed. Microcrystalline cellulose is also capable of emulsifying, that is, preventing the separation of oils and other ingredients that would not normally mix. Microcrystalline cellulose prevents powders from caking, stabilizes foam consistency, and makes frostings and toppings opaque for visual appeal.

Another area where cellulose is useful to food manufacturers is in adding bulk. Microcrystalline cellulose is used as a filler to increase the volume and mass of a product while reducing the use of more expensive items like flour, sugar or fat. As an added advantage, cellulose is not digested, so it does not add any calories to food. In fact, cellulose also has the ability to hold moisture, so it is used as a fat replacement; for example, it is added to prepared, diet meat products to make them juicy without fat content.

Cellulose is a natural polysaccharide (complex carbohydrate) found in all plant material. Microcrystalline cellulose consists of a specific segment of the cellulose molecule, which is chemically “snipped off” and isolated into a powder. There are several forms of microcrystalline cellulose, each performing different functions. One form is used in nutritional supplements as dietary fiber. Microcrystalline cellulose is used as an alternative to a modified cellulose, such as carboxymethyl, or hydroxypropyl cellulose.