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Microsrystalline cellulose,Sodium Carboxymethyl Cellulose,Hydroxypropyl Methyl Cellulose Manufacturer

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sodium carboxymethyl cellulose pharmaceutical uses

Sodium Carboxymethyl cellulose appears as white, fibrous, free-flowing powder, and is used commonly as an FDA-approved disintegrant in pharmaceutical manufacturing. Disintegrants facilitate the breakup of a tablet in the intestinal tract after oral administration. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Polymers of carboxymethylcellulose sodium are also the active ingredient in many over-the-counter dry-eye or “natural tears” products, such as Refresh Tears or TheraTears Lubricant Eye Drops.

According to the FDA Select Committee on GRAS food Substances, carboxymethylcellulose sodium is virtually unabsorbed. Carboxymethylcellulose sodium is generally regarded as safe when used in normal quantities.

Generally Sodium Carboxymethyl cellulose Used in Pharmaceutical for Suspension, Thickening and Stabilizing.

Sodium Carboxymethy Cellulose Used in Food Industry

FAO and WHO have agreed to use pure sodium carboxymethylcellulose sodium cc for food, which is subject to very stringent biology, toxicology research and experimental consent, the international standard safe intake (ADI) is 25mg / (Kg · d), that is about 1.5 g / d per person. It has been reported that some people had an experimental intake of 10 kg and no toxic response. Carboxymethylcellulose CMC is not only an outstanding emulsifying stabilizer, thickener, but also has excellent freeze, melting stability, and can improve the flavor of the product and extend the storage time. In soy milk, ice cream, ice cream, jelly, beverages, cans in the amount of about 1% to 1.5%. CMC can also be vinegar, soy sauce, vegetable oil, fruit juice, gravy, vegetable juice and other components constitute a stable emulsion of lax, the amount of 0.2% to 0.5%. Especially the dynamic, vegetable oil, protein and aqueous emulsion function is extremely good, can make it constitute a stable homogeneous emulsion. Because of its safe and reliable, therefore, its use is not subject to national food hygiene standards ADI constraints. Carboxymethylcellulose CMC has been developed in the food field, and the use of sodium carboxymethyl cellulose in wine production has also been initiated.
Sodium carboxymethyl cellulose
Sodium carboxymethyl cellulose is directly mixed with water and formulated as a paste-like glue. In the equipment CMC paste, first with a mixing device in the mixing tank to participate in a certain amount of clean water, open the mixing equipment in the case, the CMC slowly evenly spread into the ingredients tank, mixing, so that CMC and Water completely blended, CMC can be enough to melt. In the melting CMC, the reason to be evenly dispersed, and constantly mixing, the intention is to “in order to avoid CMC and water meet, the agglomeration, agglomeration, decreased CMC dissolved amount of doubt”, and improve the dissolution rate of CMC. Mixing moments and moments when CMC is completely dissolved are two concepts. Generally speaking, the time of mixing is much shorter than the time required for the CMC to dissolve completely, depending on the circumstances.
The mixing time is determined by the fact that when the sodium carboxymethyl cellulose is uniformly lazed in water and no significant large agglomerates are present, the mixing can be stopped and the CMC and water are allowed to soak with each other in a standing condition, Blend with each other.
Assuming that the time required for the complete melting of carboxymethyl cellulose sodium cmc is based on several aspects:
(1) CMC and water completely bonded, there is no solid-liquid separation between the two;
(2) mixed paste was uniform and common situation, the appearance of smooth lubrication;
(3) mixed paste color close to colorless and bright, no paste in the granular objects. From the CMC was put into the mixing tank and water mixed with the beginning, to the CMC completely dissolved, the required time between 10 to 20 hours.
Sodium carboxymethyl cellulose (CMC) is anionic cellulose ether, the appearance of white or yellowish flocculent fiber powder or white powder, odorless and tasteless, non-toxic; soluble in cold water or hot water, constitute a certain viscosity Of the bright solution. The solution is neutral or slightly alkaline, insoluble in ethanol, ether, isopropyl alcohol, acetone and other organic solvents, soluble in water containing 60% ethanol or acetone solution. There is hygroscopicity, the stability of the heat, the viscosity decreases with the temperature rise, the solution in the PH value of 2 to 10 stable, PH less than 2, a solid separation, PH value is higher than 10 viscosity decreased. Discoloration temperature 227 ℃, carbonization temperature 252 ℃, 2% aqueous solution external tension 71mn / n.

Guidance for Making Sodium Carboxymethyl Cellulose Solution

Food Additives Sodium carboxymethyl starch is everywhere in the food industry. Food additives are modern food industry products, no food additives, food can not be as colorful as it is now. Reasonable and legitimate use of food additives, will not affect food safety. Green, natural is now a lot of people choose an important basis for purchasing food. So food additives also began to natural.

The production and use of natural food additives in China has a long history, with the vigorous development of the food industry, China’s natural food additives industry has begun to take shape. China’s red yeast rice, red yeast rice, red chrysanthemum, chili pepper resin, pepper red, sorghum red, caramel, march yellow, cocoa shell brown, shellac red, chlorophyll copper sodium and other edible natural pigments are also sold foreign. China has produced natural food additives rich capital, vigorously develop the “natural, nutrient, multi-functional” edible natural additives at the time.

Pure natural thickener is not terrible

Sodium carboxymethyl starch

The thickener sounds a bit scary and could have been met every day. Have you seen the egg soup in the cafeteria or in the restaurant? Experienced chefs use only one egg to let a vat soup look like floating a lot of eggs, the trick is to thicken. Starch caused a wonderful change in science called “gelatinization”, it makes the soup becomes thick, so that egg flowers evenly suspended in the soup, rather than sink to the bottom of the barrel. Starch was originally the most simple thickener.

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It is reported that the food additives in the thickening agent 30 kinds of mercy, they give food sticky, suitable for the taste. The most common of these thickeners are modified starch and gums, such as sodium carboxymethyl starch, hydroxypropyl starch, guar gum, xanthan gum, pectin, gelatin and the like. Many thickeners are from natural foods, such as sodium alginate, agar and so on. Xanthan gum is also corn starch after microbial fermentation, to some extent, is also natural.

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Gu Zhenhua pointed out that in food food can not increase the chemical synthesis of additives. But one thing to note is that, for example, putting some glutinous rice in the porridge also has a thickening effect, it is also a thickener, and its attribution to the food itself thickening, not in the scope of chemical synthesis additives. In some of our country, will be in the porridge put alkali to play the effect of thickening, nor in the scale of which. But not initiated in the porridge put alkali, will damage the vitamin B.

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Consumers need natural antiseptic

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The baking industry is listening to consumers about the growing need for natural preservatives, but this is a difficult area to go on track. “In terms of shelf life and quality control, preservatives are important in our food production, but they are usually of a chemical nature, so consumers will have them,” explains Morley, a recent European FIE in Frankfurt. As a bit of artificial feeling, in the consumer’s food, they are the best to see more natural preservatives, “said the manager.

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Morley noted that as consumers demand this kind of baking industry, several companies are struggling to propose solutions for natural preservatives that still exist in producing quality natural preservatives. “In fact, I thought it was one of the harder reach.” The preservative was a mixture, and when you were actually from a well-known, very characteristic, useful man-made mixture to a natural preservative, its function was It ‘s hard to match, it’ s a hard – going area.

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Morley shows that the start of the producer to the natural preservative is perhaps a bit of a substitute. “If you switch from artificial preservatives to natural preservatives, then you may need to introduce other factors to compensate for the relative poor function of natural preservatives.”

Hydroxypropyl methyl cellulose

Hydroxypropyl methyl cellulose, the whole process in the automatic monitoring of the end, does not contain any animal organs and grease and other active ingredients, non-ionic cellulose ether, the appearance of white powder, odorless and tasteless.
2 traits
Hydroxypropylmethylcellulose Molecular formula
Hydroxypropylmethylcellulose Molecular formula
Soluble in water and most of the polarity c and the appropriate share of ethanol / water, propanol / water, dichloroethane and so on, in ether, acetone, ethanol insoluble, swollen in cold water to clear or slightly cloud Colloidal solution. The aqueous solution has a surface activity, high transparency and a stable function. HPMC has the nature of hot gel, commercial water solution after the composition of gel separation, cooling and then dissolved, not the same as the standard commodity gel temperature is not the same. Solubility changes with viscosity, the lower the viscosity, the greater the solubility, not the same as the standard HPMC its nature must be different, HPMC dissolved in water is not affected by the PH value. Particle size: 100 mesh pass rate greater than 98.5%. Bulk density: 0.25-0.70g / (usually 0.4g / mercy), the proportion of 1.26-1.31. Color change temperature: 180-200 ° C, carbonization temperature: 280-300 ° C. The oxygen value is 19.0% to 30.0%, and the hydroxypropyl value is 4% ~ 12%. Viscosity (22 ℃, 2%) 5 ~ 200000mPa .s. Gel temperature (0.2%) 50 to 90 ° C. HPMC has the characteristics of thickening ability, salt discharge, pH stability, water retention, scale stability, excellent film-forming property and extensive resistance to enzyme, laxity and adhesion.
3 primary use
1. Construction: As a cement mortar water retaining agent, retarder to make mortar with pumping. In the plaster, gypsum material, putty powder or other building materials as a binder, progressive modification and extension of the operation time. Used for posting tiles, marble, plastic decoration, posting enhancer, but also to reduce the amount of cement. HPMC’s water retention function allows the slurry to be cracked and dry after hardening.
2. Ceramic manufacturing industry: in ceramic production is widely used as a binder.
3. Coating industry: in the paint industry as a thickener, auxiliaries and stabilizers, in water or organic solvents are outstanding compatibility. As a paint remover.
4. Ink printing: In the ink industry as a thickener, auxiliaries and stabilizers, in water or organic solvents are outstanding compatibility.
5. Plastic: forming mold release agent, softener, smooth agent and so on.
6. Polyvinyl chloride: PVC production as a slag, the suspension polymerization of PVC preparation of the main additives.
7. Other: This product is also widely used in leather, paper products industry, fruit and vegetable preservation and textile industry.
8. Medicine Occupation: coating information; membrane material; sustained-release preparation of the speed control polymer material; stability agent; suspending agent; tablet adhesive;
Chemical properties
1, Appearance: white or almost white powder.
2, particle size; 100 mesh pass rate greater than 98.5%; 80 mesh pass rate of 100%. Special standard particle size of 40 to 60 mesh.
3, carbonization temperature: 280-300 ℃
Hydroxypropylmethylcellulose
Hydroxypropylmethylcellulose
4, depending on the density: 0.25-0.70g / cm (usually 0.5g / cm or so), the proportion of 1.26-1.31.
5, color temperature: 190-200 ℃
6, surface tension: 2% aqueous solution is 42-56 dyn / cm.
7, dissolved function: soluble in water and some solvents, such as the appropriate share of ethanol / water, propanol / water and so on. The aqueous solution has a surface activity. High transparency, functional stability, not the same as the standard product gel temperature is not the same, the solubility changes with viscosity, the lower the viscosity, the greater the solubility, not the same standard HPMC its function must be different, HPMC dissolved in water from pH Value effect.
8, HPMC with the methoxy content reduction, gel point increased, decreased water solubility, surface activity also decreased.
9, HPMC also has the ability to thicken, salt and low ash powder, pH stability, water retention, scale stability, excellent film-forming, and a wide range of resistance to enzymes, laxity and adhesion characteristics.
5 composition approach
1. The purified cotton cellulose is treated with lye at 35-40 ° C for half an hour, pressed, the cellulose is destroyed, and aged at 35 ° C, so that the resulting alkali fiber is uniformly polymerized within the desired range. The alkali fibers were put into an etherification kettle, followed by propylene oxide and methyl chloride, etherified at 50-80 ° C for 5 hours, and a maximum pressure of about 1.8 MPa. And then in the hot water at 90 ℃ to participate in appropriate hydrochloric acid and oxalic acid scouring materials, so that the volume expansion. Dehydrated with a centrifuge. Scrub to neutral, when the water content of less than 60%, the hot air flow at 130 ℃ boring to 5% or less.
6 dissolving method
1. All types are able to use dry mixing method to participate in the guess;
2. Demand directly to participate in the aqueous solution at room temperature, the best choice of cold water lax type, usually after 10-90 minutes to participate in thickening;
3. General type of hot water mixed with the first lax, to participate in cold water after mixing can be dissolved;
4. Dissolution, such as the formation of agglomeration package appearance, because the mixing is not sufficient or the general type of direct participation in the cold water reasons, this time should be quickly mixed.
5. If the bubble occurs, it can be left for 2-12 hours (detailed solution from the solution consistency) or vacuum, pressure and other methods to remove, can also participate in the appropriate defoamer.
Application areas
Construction industry
1, cement mortar: improve the stability of cement – sand, a substantial improvement in the plasticity of the mortar and water retention, to avoid the crack useful fruit, can enhance the strength of cement.
2, tile cement: the progress of the suppression of tile plastic mortar, water retention, progressive tile adhesive, to avoid powder.
3, asbestos and other refractory materials: as a suspension agent, mobility improver, but also improve the bonding of the substrate.
4, gypsum coagulation slurry: to improve water retention and processing, improve the adhesion of the substrate.
5, seam cement: increased in the gypsum board with the joints of cement, improve the mobility and water retention.
6, latex putty: to improve the resin latex as the basis of the flow of fresh air and water retention.
7, plaster: as a substitute for the natural matter of the paste, can improve the water retention, progress with the base of the glue force.
8, paint: as a latex paint plasticizer, to improve the coating and putty powder operation function and the improvement of liquidity useful fruit.
9, spray coating: to avoid the cement or latex coating only material filler sinking and improve the mobility and spray beam graphics have an outstanding role.
10, cement, gypsum secondary products: as cement – asbestos and other hydraulic material extrusion molding adhesive use, improve mobility, can get a uniform molding.
11, fiber wall: because the anti-bacterial anti-bacterial role, as a sand wall adhesive is useful.
12, the other: can be used as a thin glue mortar and mud hydraulic operator role (PC version) of the bubble holder.
chemical industry
1, vinyl chloride, vinylidene polymerization: as the polymerization of the suspension agent, a disinfectant, with vinyl alcohol (PVA) hydroxypropyl cellulose (HPC) and can be used to control the distribution of particles and particles.
2, adhesive: as a wallpaper adhesive, alternative starch is usually able to use with vinyl acetate latex paint and use.
3, pesticides: increased in pesticides, herbicides, can improve the adhesion when the eruption.
4, latex: progressive asphalt latex emulsion emulsifier, styrene butadiene rubber (SBR) latex thickener.
5, binder: as a pencil, crayon forming adhesive.
Cosmetics industry
1, shampoo: progressive shampoo, detergent, detergent viscosity and the stability of the bubble.
2, toothpaste: to improve the mobility of toothpaste.
food industry
1, canned citrus: to avoid the retention of citrin because of differentiation and whitening transformation and achieve the preservation effect.
2, cold fruit finished products: increased in the fruit dew, ice and so on, so that the taste is very good.
3, sauces: as a sauce, tomato sauce, emulsifying anesthetic or thickener.
4, cold water coating polishing: for frozen fish storage, to avoid discoloration, quality decline, with methyl cellulose or hydroxypropyl methyl cellulose aqueous solution coated with glazing, and then frozen on the ice.
5, the pill of the adhesive: as a tablet, the formation of adhesive tablets, adhesive “together with the collapse of the” (when taking agile melting disintegration) outstanding.
Pharmaceutical industry
1, package complex: the package agent made of organic solvent solution or aqueous solution tablets, in particular, to the resulting particles spray package complex.
2, slow down the agent: 2-3 grams per day, each 1-2G of the amount of material, in 4-5 days show the role.
3, eye drops: because the methyl cellulose aqueous osmotic pressure and tears, so the impact on the eyes of small, increase eye drops, as touch the eye of the crystal smooth agent.
4, jelly: as jelly-like external drug may be the base material.
5, impregnating agent: as a thickening agent, water retaining agent.
Kiln career
1, electronic information: as a ceramic ionizer, ferrite bauxite out of the extrusion molding of the adhesive, with 1.2-propylene glycol and use.
2, glaze: used as ceramic glaze and porcelain cooperation, can improve the bonding and processing.
3, refractory mortar: increase in the refractory mortar or pouring furnace, can improve the plasticity and water retention.
Other occupations
1, fiber: as a printing and dyeing paste for pigments, boron soil dyes, salt-based dyes, textile dyes, in addition, kapok in the corrugated processing, with the thermal hardening resin and use.
2, paper: used to copy the paper on the leather surface and oil processing and so on.
3, leather: as a final smooth or one-time use of adhesive.
4, water-based ink: increased in water-based ink, ink, as a thickening agent, film-forming agent.
5, tobacco: as a renewable tobacco binder.

Sodium Carboxymethyl Cellulose Application

1. What are the effects and uses of sodium carboxymethyl cellulose in the food industry: FAO and WHO have approved the use of pure cmc for food, which is approved after rigorous biology, toxicology research and testing (ADI) of the international standard is 25 mg / (kg · d), that is, about 1.5 g / a per person. It has been reported that some people test the intake of 10 kg did not have toxic reactions. CIVIC in food applications is not only a good emulsion stabilizer, thickener, but also has excellent freezing, melting stability, and can improve the flavor of the product, to extend the storage time. In soy milk, ice cream, ice cream, jelly, beverages, cans in the amount of about 1% to 1.5%. CMC can also be used with vinegar, soy sauce, vegetable oil, fruit juice, gravy, vegetable juice and other stable performance of the emulsion dispersion, the amount of 0.2% to 0.5%. Especially for the dynamic, vegetable oil, protein and aqueous emulsion performance is extremely excellent, can make it stable performance homogeneous emulsion. Because of its safe and reliable, therefore, its use is not subject to national food hygiene standards ADI restrictions. CMC has been developed in the field of food, in recent years, the application of sodium carboxymethyl cellulose in wine production research has also been carried out.
2. What is the efficacy and use of sodium carboxymethyl cellulose in the pharmaceutical industry? In the pharmaceutical industry can be used as an injection of emulsifying stabilizer, tablet binder and film-forming agent. Some people through the basic and animal experiments show that CMC is safe and reliable anti-cancer drug carrier. Using CMC as the membrane material, the development of Chinese medicine Yangyin sorex powder modified dosage form – – Yin Yin sarcoma, can be used for skin grinding surgical wound and traumatic wound. Animal model studies have shown that the film prevents wound infection, and no significant difference with the gauze dressing, in the control of wound tissue fluid exudation and wound healing, the film was better than gauze dressing, and reduce the postoperative edema and wound stimulation. With the polyvinyl alcohol: sodium carboxymethyl cellulose: polycarboxylate 3: 6: 1 ratio of the film made of the best prescription, adhesion and release rate are increased in the mucosal adhesive sustained-release film The adhesion of the agent to extend the retention time in the oral cavity and the efficacy of the drug in the preparation are significantly improved. Bupivacaine is a potent topical anesthetic, but it can sometimes produce more severe cardiovascular side effects when poisoning, so the clinical application of bupivacaine in clinical practice, its toxicity research has been more attention. Pharmacy studies have shown that CIVIC formulated as a sustained-release substance with a picocaine solution significantly reduces the side effects of the drug. In the PRK operation, the use of low concentrations of caine and non-steroidal anti-inflammatory drugs combined with CMC can significantly relieve postoperative pain. Prevention of abdominal surgery after peritoneal adhesions, reduce the occurrence of intestinal obstruction is one of the most concerned about clinical surgery. Studies have shown that CMC to reduce the degree of postoperative peritoneal adhesions was significantly better than sodium hyaluronate, can be used as an effective way to prevent the occurrence of peritoneal adhesions. CMC for the treatment of liver cancer ductal hepatic artery infusion of anti-cancer drugs, can significantly extend the anticancer drug in the tumor retention time, enhance the anti-tumor force, improve the therapeutic effect. In animal medicine, CMC also has a wide range of uses. It has been reported that 1% CMC solution is infused into the ewes of the ewes to prevent the dystocia of livestock, and there is a significant effect on abdominal adhesions after genital tract surgery.
What is the efficacy and use of sodium carboxymethyl cellulose?
3. What is the efficacy and use of sodium carboxymethyl cellulose in other industries:
In detergents, CMC can be used as anti-fouling redeposition agent, especially for hydrophobic synthetic fiber fabric anti-fouling redeposition effect, significantly better than carboxymethyl fiber.
What is the effectiveness and use of sodium carboxymethyl cellulose in oil drilling can be used to protect the wells as a mud stabilizer, water retaining agent, the amount of each well is shallow wells 2.3t, deep well 5.6t;
In the textile industry as a sizing agent, printing paste thickener, textile printing and stiff finishing. For the sizing agent can improve the solubility and viscosity, and easy to desizing; as a stiffening agent, the amount of more than 95%; for sizing agent, serous membrane strength, bending performance was significantly improved; with regenerated silk protein And carboxymethyl cellulose as a fixed glucose oxidase matrix, fixed glucose oxidase and carboxylic acid ferrocene, made of glucose biosensor with high sensitivity and stability. The results show that the chromatographic properties of the prepared thin plate are the best when the silica gel homogenate is prepared with CMC solution at a concentration of about 1% (w / v). At the same time, the thin plate coated under optimized conditions has The appropriate layer strength, suitable for a variety of loading technology, easy to operate. CMC is adhered to most fibers, can improve the fiber between the combination of its viscosity stability to ensure uniformity of the sizing, thereby enhancing the efficiency of weaving. Can also be used for textile finishing agent, especially the permanent anti-crease finishing, to bring the durability of the fabric changes.
What is the effectiveness and use of sodium carboxymethyl cellulose can be used as anti-settling agents, emulsifiers, dispersants, leveling agents, adhesives, paint can make the solid evenly distributed in the solvent, the paint long-term Not layered, but also a large number of applications in the paint.
What is the effectiveness and use of sodium carboxymethyl cellulose used as a flocculant in the removal of calcium ions than sodium gluconate more effective for cation exchange, the exchange capacity of up to 1.6 ml / g.
What is the effectiveness and use of sodium carboxymethyl cellulose in the paper industry as a paper sizing agent, can significantly improve the paper dry strength and wet strength and oil resistance, ink absorption and water resistance.
What is the efficacy and use of sodium carboxymethyl cellulose in cosmetics as a hydrosol, used as a thickener in toothpaste, the amount of about 5%.
Sodium Carboxymethyl Cellulose What is the efficacy and use of flocculants, chelating agents, emulsifiers, thickeners, water retaining agents, sizing agents, film forming materials, etc., is also widely used in electronics, pesticides, leather, plastic, printing , Ceramics, household chemicals and other fields, and because of its excellent performance and wide range of uses, is still constantly open up new applications, the market prospect is extremely broad.
Carboxymethyl cellulose sodium cmc is odorless, odorless, non-toxic, easy to absorb moisture of white or yellowish particles and fibrous powder, which has excellent water solubility, viscose, milk, diffuse, anti-enzyme Sexuality and stability. The solution of carboxymethyl cellulose sodium CMC is a colorless transparent colloid, and the transparency is improved with the increase of the degree of substitution. The aqueous solution of sodium carboxymethyl cellulose sodium was neutral or weakly alkaline.
Since the carboxymethyl cellulose sodium CMC has the above characteristics, it is possible to make a sizing agent, an emulsifier, a stabilizer, a binder, a suspending agent, a thickening agent, a builder, a polishing agent, a crystallization production preventing agent, Used in textile, printing and dyeing, oil, paper, leather, ink, ceramics, artificial fur, synthetic washing, putty powder, imitation porcelain coating, construction glue, cigarette, putty cream, ceramics, food and medicine and other industries. With the continuous improvement of technology, application prospects will be more extensive.
Sodium carboxymethyl cellulose is white fibrous or powdered, colorless and odorless, non-toxic, insoluble in organic solvents such as acid and ethanol, soluble in water, alkaline or medium transparent transparent liquid, and Other water-soluble softeners, tree fingers are compatible.
Uses: with adhesion, thickening, enhanced, emulsified, water, suspension and so on.
1, textile printing and dyeing industry: instead of grain as sizing agent, printing paste thickener and emulsifier.
2, daily chemical industry: household chemical products such as synthetic detergent, soap, toothpaste and other stabilizers, emulsifiers.
3, the paint industry: in the paint printing, as a stabilizer, emulsifier.
4, paper industry: as a paper smoothing agent.
5, ceramic industry: ceramic blank for the adhesive, in the glaze for the suspension agent.
6, the oil industry: as a drilling mud, well fluid treatment agent.
7, food: as a food processing industry as a thickener.
8, other aspects: for the shoe hats, pencils, mosquito coils, tobacco and other adhesives, polish on the leather, coloring agent, foam fire extinguisher stabilizer.
This product has a bonding, thickening, enhanced, emulsified, water, suspended and other purposes
1. What is the efficacy and use of sodium carboxymethyl cellulose in the food industry: FAO and WHO have approved the use of pure CMC for food, which is approved after rigorous biology, toxicology research and testing , The international standard safe intake (ADI) is 25mg / (kg · d), that is about 1.5 g / a per person. It has been reported that some people test the intake of 10 kg did not have toxic reactions. CIVIC in food applications is not only a good emulsion stabilizer, thickener, but also has excellent freezing, melting stability, and can improve the flavor of the product, to extend the storage time. In soy milk, ice cream, ice cream, jelly, beverages, cans in the amount of about 1% to 1.5%. CMC can also be used with vinegar, soy sauce, vegetable oil, fruit juice, gravy, vegetable juice and other stable performance of the emulsion dispersion, the amount of 0.2% to 0.5%. Especially for the dynamic, vegetable oil, protein and aqueous emulsion performance is extremely excellent, can make it stable performance homogeneous emulsion. Because of its safe and reliable, therefore, its use is not subject to national food hygiene standards ADI restrictions. CMC has been developed in the field of food, in recent years, the application of sodium carboxymethyl cellulose in wine production research has also been carried out.
2. What is the efficacy and use of sodium carboxymethyl cellulose in the pharmaceutical industry? In the pharmaceutical industry can be used as an injection of emulsifying stabilizer, tablet binder and film-forming agent. Some people through the basic and animal experiments show that CMC is safe and reliable anti-cancer drug carrier. Using CMC as the membrane material, the development of Chinese medicine Yangyin sorex powder modified dosage form – – Yin Yin sarcoma, can be used for skin grinding surgical wound and traumatic wound. Animal model studies have shown that the film prevents wound infection, and no significant difference with the gauze dressing, in the control of wound tissue fluid exudation and wound healing, the film was better than gauze dressing, and reduce the postoperative edema and wound stimulation. With the polyvinyl alcohol: sodium carboxymethyl cellulose: polycarboxylate 3: 6: 1 ratio of the film made of the best prescription, adhesion and release rate are increased in the mucosal adhesive sustained-release film The adhesion of the agent to extend the retention time in the oral cavity and the efficacy of the drug in the preparation are significantly improved. Bupivacaine is a potent topical anesthetic, but it can sometimes produce more severe cardiovascular side effects when poisoning, so the clinical application of bupivacaine in clinical practice, its toxicity research has been more attention. Pharmacy studies have shown that CIVIC formulated as a sustained-release substance with a picocaine solution significantly reduces the side effects of the drug. In the PRK operation, the use of low concentrations of caine and non-steroidal anti-inflammatory drugs combined with CMC can significantly relieve postoperative pain. Prevention of abdominal surgery after peritoneal adhesions, reduce the occurrence of intestinal obstruction is one of the most concerned about clinical surgery. Studies have shown that CMC to reduce the degree of postoperative peritoneal adhesions was significantly better than sodium hyaluronate, can be used as an effective way to prevent the occurrence of peritoneal adhesions. CMC for the treatment of liver cancer ductal hepatic artery infusion of anti-cancer drugs, can significantly extend the anticancer drug in the tumor retention time, enhance the anti-tumor force, improve the therapeutic effect. In animal medicine, CMC also has a wide range of uses. It has been reported that 1% CMC solution is infused into the ewes of the ewes to prevent the dystocia of livestock, and there is a significant effect on abdominal adhesions after genital tract surgery.
3. What is the efficacy and use of sodium carboxymethyl cellulose in other industries:
In detergents, CMC can be used as anti-fouling redeposition agent, especially for hydrophobic synthetic fiber fabric anti-fouling redeposition effect, significantly better than carboxymethyl fiber.
In the oil drilling can be used to protect the oil wells as a mud stabilizer, water retaining agent, the amount of each well is shallow wells 2.3t, deep wells 5.6t;
In the textile industry as a sizing agent, printing paste thickener, textile printing and stiff finishing. For the sizing agent can improve the solubility and viscosity, and easy to desizing; as a stiffening agent, the amount of more than 95%; for sizing agent, serous membrane strength, bending performance was significantly improved; with regenerated silk protein And carboxymethyl cellulose as a fixed glucose oxidase matrix, fixed glucose oxidase and carboxylic acid ferrocene, made of glucose biosensor has a high sensitivity and stability. The results show that the chromatographic properties of the prepared thin plate are the best when the silica gel homogenate is prepared with CMC solution at a concentration of about 1% (w / v). At the same time, the thin plate coated under optimized conditions has The appropriate layer strength, suitable for a variety of loading technology, easy to operate. CMC is adhered to most fibers, can improve the fiber between the combination of its viscosity stability to ensure uniformity of the sizing, thereby enhancing the efficiency of weaving. Can also be used for textile finishing agent, especially the permanent anti-crease finishing, to bring the durability of the fabric changes.
It can be used as anti-settling agent, emulsifier, dispersant, leveling agent and binder for coating. It can distribute the solid parts of the coating evenly in the solvent, so that the coating can not be stratified for a long time and also used in paint.
Used as a flocculant in the removal of calcium ions than sodium gluconate more effective for cation exchange, the exchange capacity of up to 1.6 ml / g.
In the paper industry as a paper sizing agent, can significantly improve the paper dry strength and wet strength and oil resistance, ink absorption and water resistance.
In cosmetics as a hydrosol, used in toothpaste thickener, the amount of about 5%.
It is widely used in the fields of electronics, pesticide, leather, plastic, printing, ceramics, household chemical, etc., and it is widely used in the fields of electronics, pesticide, leather, plastic, printing, ceramics, Its excellent performance and wide range of uses, but also continue to develop new applications, the market prospect is extremely broad.
Shandong Dongda Cellulose Co., Ltd. (http://www.sdcmcchina.com/), is a professional manufacturer of sodium carboxymethyl cellulose, sodium carboxymethyl starch, xanthan gum production enterprises, specializing in the production of carboxyl Methyl cellulose sodium, sodium carboxymethyl starch, xanthan gum. Have a strong technical force, advanced production technology and equipment. Dongda Cellulose Co., Ltd. for all employees at home and abroad to provide high-tech, high-performance, high-quality products. We warmly welcome customers at home and abroad cooperation and win-win situation.